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Afolayan et al., [39] also reported that most active antimicrobial components are generally insoluble in aqueous medium, thus it is expected that organic solvents of low polarity would yield more active antimicrobial extracts.
Future studies to better define this relationship would be worthwhile, in that they would help hospitals determine where to best invest their resources to reduce the overall impact of resistance in their institutions, whether through enhanced infection control measures or more active antimicrobial stewardship, although both measures are likely important.
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Hence, there is an urgent need to discover an alternative new, broad spectrum, more active, and safer antimicrobial agent.
In addition, the more active in vitro antimicrobial agents have been characterized further in a lethal hamster model for in vivo activity.
Fractions F2-F4 (for antioxidant activity) and F4 (for antimicrobial activity) were more active than the crude extract indicating that fractionation enhanced the considered biological activities of these fractions.
The antibacterial activity of the compound (3h) was two times more active against S. epidermidis than the reference antimicrobial compound (Cefuroxime).
In addition to S. epidermidis, these three compounds (3a, 3b, and 3h) were more active against E. faecalis than the reference antimicrobial compound (Amikacin).
The compounds with intermolecular H-bonding were found more active revealing a possible relationship among hydrogen bonding, cytotoxicity and antimicrobial activities.
The oligomer has excellent antimicrobial activity and was found to be 18 times more active toward bacterial cells than human red blood cells.
In this study the honey samples were studied without fractioning to determine the antimicrobial activity, since the whole honey sample can be more active than its isolated components due to this possible synergic effect.
When the toxicity of some compounds was compared with the reference clinically proven antimicrobial drug Cefuroxime, the antibacterial activities of some compounds were 2 4 times more active than Cefuroxime [18].
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