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Indeed, in PP subjects, more activation was seen in the left posterior insula, whereas EDP subjects had greater engagement in the left precuneus and mPFC.

The key findings of this study in relation to our hypothesis is that, as predicted, L-Dopa medication restored the function of the motor cortico-striatal loop, during the execution of a set-shift since significantly more activation was found in the PMC during the ON vs. the OFF state when matching after negative feedback was compared with control matching (Figure 5).

In the reverse contrast, more activation was observed within the left and right AG, and in frontal brain areas (see Table 2 and Figure 2).

Entering Binf as a between-subject regressor in the above contrast showed that the more influenced a subject was by reviewer opinion, the more activation was found in the regions highlighted in Figure 3 during disagreement with reviewers.

Correspondingly, more activation was seen close to the cortical surface (Fig. 5 B) than close to the white matter border (Fig. 5D), suggesting that at least part of the activation may result from extra-vascular BOLD contrast due to large veins.

Similar(55)

The more activation is recorded, the greater the motivation or ability to seek and correct errors in the real world, a recent study suggests.

In the EX addition task, more activations were elicited in abacus-trained children, including the medial prefrontal cortex (MPFC), right caudate, right thalamus, right superior temporal cortex, and the right angular gyrus (see Table 3 and Figure 4), with a threshold of P < 0.011 (FDR corrected) and a minimal cluster size of 30 voxels.

In the AP addition task, more activations were elicited in abacus-trained children, including the bilateral middle temporal cortices (x, y, z = −51, −33, −3 on the left; x, y, z = 51, −18, −12 on the right) and the left precuneus (x, y, z = −3, −39, 60), with a threshold of P < 0.001 (uncorrected) and a minimal cluster size of 10 voxels.

Conversely, more activations were induced in nontrained children, including the left precentral sulcus (x, y, z = −36, −6, 36) and the left middle frontal cortex (x, y, z = −30, 15, 27), with a threshold of P < 0.05 (uncorrected) and a minimal cluster size of 30 voxels.

Conversely, more activations were induced in nontrained children, including the left precentral sulcus (x, y, z = −42, −3, 42) and the SMA (x, y, z = −6, 0, 57), with a threshold of P < 0.005 (uncorrected) and a minimal cluster size of 10 voxels.

More moderate activation was achieved by transfecting a plasmid expressing unprocessed NOTCH1 (N1-FL).

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