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Instead, oxygen plasma functionalization led to increased macrophage adhesion and spreading suggesting a more activated phenotype, confirmed by elevated cytokine release.
Spontaneous recovery from HCV infection is associated with NKT cells that demonstrate a more activated phenotype [36].
rAd immunization result in greater virus-specific CD8+ T-cell responses in the lung, but these cells also possessed a more activated phenotype than cells induced by i.m. immunization.
While the control placenta NK cells are not increased compared to CB, they do demonstrate a more activated phenotype with elevated NKG2C, CD69 and TRAIL (Figure 3 and Table S2).
In the present study, both E2 protein and HCVcc conferred Raji cells and PHB cells more activated phenotype by increasing the expressions of CD80, CD86, which are consistent with the observation that E2 promoted Raji cells to secret TNF-α [16].
In the absence of anti-4-1BB therapy, it was clear that the reactivated memory T cells were enriched in the tumor at day 4 compared to the resting memory T cells (Fig. 3) and had a more activated phenotype than the resting memory T cells or the reactivated memory T cells that had gone to the spleen or draining LN (Fig. 3B).
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As described, patients with RA display a more activated platelet phenotype, but the underlying mechanism is not clear.
Taken together, these results indicate that, although showing a great variability in morphological shape and in biological behaviour, the CHO-AFs display a more differentiated and activated phenotype than the perilesional-Fs, NAS-Fs and MEAC-Fs.
The phenotype of CMV-specific cells was both more differentiated and more activated (CD45R0+, HLA-D+) than the phenotype of the overall CD8 T-cell population, though levels of activation fell throughout the first year to the extent that by 12 months post-diagnosis, activation in the overall CD8 T-cell population was similar in CMV-infected and uninfected infants of the same age.
After 4 days following seeding, valve cells in single layer cultures showed reduced smooth muscle α-actin expression with a stabilized cell density, suggesting a transition from an activated phenotype to a more quiescent state.
In terms of absolute numbers, we have found that Stat1−/− mice have essentially normal numbers of Foxp3+ cells, but these mice have profound splenomegaly and approximately ten times more CD4+ T cells with an activated phenotype (CD25+ Foxp3−) than wild-type controls (not shown).
More suggestions(15)
more mesenchymal phenotype
more invasive phenotype
more extreme phenotype
more attenuated phenotype
more glycolytic phenotype
more pronounced phenotype
more aggressive phenotype
more subtle phenotype
more differentiated phenotype
more normal phenotype
more epithelioid phenotype
more tumorigenic phenotype
more complex phenotype
more modest phenotype
more activated platelet
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