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To more accurately recapitulate the selection process, a cDNA was designed for the intracellular expression of the yeast tRNAPhe.
For solid tumors, this would mandate the development and implementation of three dimensional (3D) in vitro tumor models that more accurately recapitulate human solid tumor architecture and biology.
We are ultimately interested in developing in vitro neuronal cultures that incorporate key constituents of the CNS, such as ECM and supporting glial cell types, to more accurately recapitulate in vivo morphology, physiology, and function.
To more accurately recapitulate the scenario of ingested ZnO NPs, we tested our as synthesized ZnO NPs in ingestion fluids (synthetic saliva and synthetic gastric juice) to determine the possible forms of ZnO NPs in digestive system before exposing the products to colorectal cell lines.
These cancers more accurately recapitulate the heterogeneity and complexity of human malignancies and as a result are linked to the problems of recurrence, resistance and metastasis.
This system allows for the introduction of somatic Oncogene delivery to a small subset of cells to more accurately recapitulate tumor initiation and further development.
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Finally, we will outline some of the challenges that lay ahead and strategies to improve and refine humanized mice with the goal of more accurately recapitulating human immune responses to viral infection.
The first step to achieve this would be to develop an animal model that more accurately recapitulates important aspects of clinical ZIKV disease as observed in humans.
Thus, the model more accurately recapitulates oncogenic processes occurring at the site of origin of BL, and these data unequivocally link PI3K signaling with MYC as cooperating factors in the development of BL.
To develop an animal model that more accurately recapitulates the human phenotype associated with PNPLA3-148M, we altered codon 148 of Pnpla3 in the mouse genome from ATT to ATG, substituting methionine for isoleucine (Pnpla3 148M) (Fig. 1A).
Previously, researchers have been confined to using single types of cells to study the effects of drugs on cells, both intended and unintended, but new ways of modeling healthy tissues, such as stem cells and organoids, together with ever-evolving methods to evaluate these models has meant that the effect of drugs can be studied on models that more-accurately recapitulate what occurs in people.
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