The exact test is used in preference to the asymptotic chi-square P-value as it is more accurate at loci where the minor allele frequency is low.
There was more variation between observed and expected DNA frequencies as the minor allele frequency increased in all datasets, showing that allele frequency estimation may be more accurate at loci with lower minor allele frequencies.
The result is a more accurate depiction of locus-specific nucleotide frequency, particularly in non-diploid regions; and allows for the joint modeling of allelic and copy number effects at a given locus.
Although Wakeley et al. [ 46] coined the more accurate term "SNP-discovered locus" (SDL) to describe these single nucleotide differences that may or may not be segregating within sampled groups, this terminology is not widely used.
The assumption of unlinked loci implies that the inheritance patterns of the loci become less dependent on each other, thereby resulting in effectively more independent loci for the ungenotyped animals, and, when averaged over many loci, more accurate estimates of relationships.
They will enable more accurate identification of piRNA loci in deep sequencing data sets.
In the future, higher coverage genomic sequences of the different primate species should allow a more accurate identification of the loci that differentiate primates closely related to humans [ 38].
REcombination Counting and ORDering (RECORD) (van Os et al. 2005a, 2005b) is a faster, more accurate method for ordering of loci on genetic linkage maps and it performs especially well in regions of maps with high marker density.
These findings suggest that while a high BLAST stringency yields more accurate predictions of sRNA-encoding loci, lowered BLAST stringency may be useful in more sensitively identifying primary sequence conservation of these loci in less closely related species.
This is not in itself a normalization issue, but it may be advantageous to minimize the differences so that the ranking of potential differentially methylated loci is more accurate [ 5].
