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The use of more accurate evolutionary models can be used to improve the design of candidate vaccine strains, particularly those based on computationally derived sequences (e.g. Center-Of-Tree (COT) [37]).
The research team consisting of Lin, Zhang and Xu [ 14] proposed a method to classify bifurcating branches of a phylogenetic tree into a set of polytomies that reflect more accurate evolutionary relationship.
A phylogenetic tree, showing ancestral relations among organisms, is commonly represented as a rooted tree with sets of bifurcating branches (dichotomies) for simplicity, although polytomies (multifurcating branches) may reflect more accurate evolutionary relationships.
While evolutionary histories are usually described by rooted phylogenetic trees, in some cases rooted phylogenetic networks may provide a more accurate evolutionary scenario, especially when mechanisms such as horizontal gene transfer, hybridization, recombination, reassortment or incomplete lineage sorting have played a role in shaping the history.
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We have changed the text to use the more accurate terms "evolutionary microbiology" and "ecological microbiology" wherever possible, while keeping the use of "Microbial Evolution" and "Microbial Ecology" when referring to those fields of science specifically.
Phylogenetic methods incorporate models of the evolutionary process, providing a more accurate representation of evolutionary relationships amongst homologous sequences.
To account for these differences between microbes and cancers (thus resulting in more accurate predictions regarding evolutionary trajectory), experimental evolution studies need to be conducted which explicitly test evolutionary theory within the context of cancer.
Darwin mixed "Lamarckian" and what was now know was his more accurate model of evolutionary change based on random mutation, stressing that he thought the latter probably were more important.
Nevertheless, the use of additional genotype 3 and 4 sequences, when available, outside China and Japan should help more accurate define the evolutionary history of HEV and most likely yield longer times to the most recent common ancestor for genotypes 3 and 4 and the genotype 3/4 ancestor.
There are always tradeoffs between incorporating more features into models and avoiding over-parameterization for more accurate captures of evolutionary information [ 19- 21].
Consequently, it gives a more accurate measure of evolutionary relatedness than cosine distance, without the need for a global alignment sequence.
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