Sentence examples for more accessible chromatin from inspiring English sources

Mechanistically, CAF-1 suppression led to a more accessible chromatin structure at enhancer elements early during reprogramming.

Chromatin of children transformed into a hyper-activated and more accessible chromatin state in response to maternal smoking, especially in regulatory regions of the genome, so called enhancer regions.

Importantly, in unexposed CAST/EiJ mice, which acquired relatively less 1,3-butadiene-induced DNA damage, we observed increased transcription and a more accessible chromatin landscape around genes involved in detoxification pathways.

It was suggested that cancer cells adopt a more accessible chromatin landscape, similar to ESCs.

It also, however, raises the question of how histone H3.3 may confer a more accessible chromatin environment.

During S phase, KDM4A demethylase activity counteracts HP1γ binding at heterochromatic regions, creating more accessible chromatin required for passage of the DNA replication machinery [ 174].

Although a generally higher efficiency of CRISPR/Cas9-induced HDR (3.8 4.3%) was observed compared with TALEN-induced HDR (0.8 1.5%), conclusions cannot be made before the following possibilities are excluded: more accessible local chromatin structure or different donor sequences.

In UNG−/− cells, enrichment of γ-H2AX occurred more frequently in accessible chromatin; TSS, DNAse-hypersensitivity regions, and origins of replication tend to be nucleosome-depleted and more readily accessible to proteins.

For example, acetylation of N-terminal lysine residues generates a more open and accessible chromatin configuration [3] [5] and is associated with increased gene expression.

Transcriptional activation of Slc17a6 was stochastic and correlated with both reduced promoter DNA methylation and significant enrichment for H3K4me3, suggesting a more open and accessible chromatin conformation.

Together, these results indicate that different chromatin-remodeling complexes in the INO80 family perform different functions in DSB repair to make chromatin more accessible for repair and signaling factors via mechanisms of histone acetylation and nucleosome remodeling.