Recent studies suggest that community-wide or environmental interventions aimed at increasing use of leisure facilities [ 26] or promoting active travel [ 27] may have more acceptable cost-effectiveness.
Achieving good health for people with T2DM requires active self-management; however, uptake of self-management education is poor, and there is an urgent need to find better, more acceptable, cost-effective methods of providing self-management support.
Pound et al 21 also found evidence to suggest that patients are often motivated to minimise their use of medication to reduce the dose of medication while still achieving some gain or to make the regime more acceptable or cost-effective.
That is, to present an ICER acceptability curve, which gives the probability (in %) that the treatment is more acceptable from a cost-effectiveness point of view than its alternative, given various ceilings for the willingness to pay (WTP) for a PD-free survival of three months.
The median incremental cost-effectiveness ratio is €6,198 (95% CI 2,435 – 60,731) per PD-free survival gained, which has a likelihood of 75.2% of being more acceptable from a cost-effectiveness point of view than care-as-usual when a willingness-to-pay ceiling is assumed of €10,000 per PD-free survival.
It can be concluded that there is a probability larger than 75% that the intervention is more acceptable from a cost-effectiveness point of view than care-as-usual when the willingness to pay (WTP) for a PD-free survival time of three months has a ceiling of €10,000.
Continued refinement of practical tools for detecting mild HAND [ 141] may also make screening more acceptable and lower the cost of collection of much-needed longitudinal data.
The Monte Carlo sensitivity analysis indicated that the likelihood of CLE being either "dominant" (ie, better clinical outcome with lower cost) or more effective at an acceptable cost was 93% even when all uncertainties associated with the model were taken into account.
Encouraging patients to participate in treatment decisions would be a much more acceptable way of ensuring cost-effective care is provided, improving compliance with ethical standards and reducing the incidence of unnecessary treatments.
Our analysis demonstrates that given a screening schedule (ie, age range and screening interval), two-sample FIT strategies with the mean from both test results being positive or at least one positive test outcome provide more LYG at acceptable costs than one-sample FIT screening.
Lower effectiveness and higher costs are more acceptable for patients with high-risk of fractures.
