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One or more abnormalities are found in almost all patients [11, 21].
More abnormalities are seen by the third trimester and a single early scan may miss some fetal anomalies.
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Some believe that finding more abnormalities is the right strategy to improve the nation's health, but how much it reduces death and disability is open to debate.
Estimated RRs for participants with three abnormalities and four or more abnormalities were 4.56 (2.48–8.78) and 10.88 (5.77 20.50), respectively, in the British Regional Heart Study (10).
In the Framingham Offspring Study, the estimated RR for participants with three or more abnormalities was 23.83 5.80–98.01) among men and 29.69 (9.10–96.85) among women (22).
More profound abnormalities are expected as chronic migraine is regarded as a clinical worsening.
However, in mainly adult BD patients with multiple episodes more structural abnormalities are found, including ventricle enlargement [ 30], white matter hyperintensities and cerebellar abnormalities [ 19].
Complex karyotypes (CK), defined as the presence of three or more chromosomal abnormalities, are detected in nearly 16% of patients [ 4, 78] and have been associated with unmutated IGHV status and CD38 expression [ 78].
In healthy subjects, this task is even more difficult, as abnormalities are more subtle and of less obvious clinical consequence, at least in the short-term.
People with MetS (three or more metabolic abnormalities) were more likely to have ischemic heart disease and stroke and to be taking hypertension medications.
Because more severe metabolic abnormalities are present in individuals with IFG + IGT, diabetes develops more rapidly and unfavorable cardiovascular risk factors and mortality are increased compared with individuals with IFG only or IGT only (36– 36).
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