Sentence examples for more Myc phenotypes from inspiring English sources

Given that each of the four mutant Myc proteins was in some way defective for one or more Myc phenotypes, we next asked how they affected transformation.

We report here that many Myc phenotypes, including the Warburg effect and enhanced OXPHOS, can be genetically uncoupled.

We were particularly interested in Q131R, which was most restricted in its ability to confer any of the non-transforming Myc phenotypes thus far examined.

One mutation (Q131R) was greatly impaired for nearly all of the studied Myc phenotypes, yet was able to retain some ability to transform.

These studies again suggest these processes are under distinct forms of genetic regulation as has been shown for other Myc phenotypes [15].

Therefore, future studies, focusing on molecular mechanisms for c-Myc-induced checkpoint alteration and sensitisation to apoptosis, are required to determine how the two remarkable Myc phenotypes are related in terms of different c-Myc target genes.

Consistent with recent reports demonstrating the essential role of Myc in K-Ras-driven tumorigenesis [ 38], the strong Myc phenotype displayed by Rasless cells is noteworthy, as seen from the detection of direct transcriptional repression of the Myc proteins (Additional file 1: Table S1) as well as of many recognized Myc transcriptional targets (Additional file 2: Table S2-TF).

We have included an analysis of FAMAp RBR-MYC phenotypes and expression in FAMAp RBR-MYCre suphenotypes C-F.

Since IMR-32 has N-Myc amplification and a more immature phenotype than SH-SY5Y, we examined in more detail the IMR-32 shTLX clones and compared them with the wild type and vector controls.

This occurs despite the re-differentiation of previously c-Myc-activated tumour cells to a more mature phenotype and the loss of some of the newly acquired vasculature, occurring during the period of c-Myc inactivation.

The potential contributions of a more global Myc chromatin function to neuroblastoma genesis and delineating the mechanisms by which Myc contributes to iPSC biology await future study.