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The population rates of psychiatric morbidity were obtained from the National Comorbidity Survey.

Hazard ratios (HR) with 95% confidence intervals (CI) for mortality and psychiatric morbidity were obtained with Cox regression models, which were adjusted for immigrant status and psychiatric morbidity prior to sex reassignment (adjusted HR [aHR]).

Data on CVD morbidity were obtained through linkage with the national medical registry.

Data concerning renal disease and morbidity were obtained from case records, and levels of comorbidity were assessed using The Index of Coexistent Disease [ 14].

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Morbidity was obtained from the Danish National Patient Register in which all hospital contacts, diagnoses, and invasive procedures have been recorded since 1978 according to the International Classification of Diseases (ICD), i.e. ICD-8 until 1994 and ICD-10 thereafter.

Information on sociodemographic and pregnancy risk factors for maternal morbidity was obtained from the birth and/or hospital data.

Once the projection of the future population morbidity was obtained, the next step in the process involved the evaluation of costs.

The best combination of positive and negative predictive values for major postoperative morbidity was obtained for a combined index (ScVO2 < 68% and blood lactate > 3 mmol/L).

Morbidity was obtained from the Danish National Patient Register, wherein all hospital admissions, out-patient consultations, diagnoses, and procedures have been recorded since 1978 according to the ICD (ICD-8 until 1994 and ICD-10 thereafter).

Recent-month self-reported morbidity was obtained in the question "Have you been ill over the past month?", an indicator of diagnosed disease plus self-perceived disease (due to uncomfortable symptoms).

Total DALYs loss from morbidity was obtained by multiplying age-specific disease incidence by the average disability loss (1-HSV) and by the time spent in the morbid condition, obtained from the WHO [ 26] or from the survey of dialysis patients for ESRD [ 19].

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