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The differences observed reflect differences in morbidity for which the SOFA score was designed.
With regards to morbidity outcomes, treatment for ROP was the only morbidity for which a statistically significant effect was observed across analyses.
Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease characterized by flares of high morbidity for which we have no predictors.
Second, the reason why these patients were tested for C-reactive protein remains unclear and there is a possibility that they might have had concurrent morbidity for which they were clinically investigated.
One study (Gangaram et al 39) reported results for adverse outcome, including maternal morbidity, for which the sensitivity was 0.55 (0.23 to 0.83) and specificity was 0.57 (0.48 to 0.65), and perinatal death, for which the sensitivity was 0.82 (0.48 to 0.98) and specificity was 0.59 (0.51 to 0.67).
Prescription databases do not usually include information about the morbidity for which the drug was prescribed and only few studies have focused on health problems as predictors of polypharmacy, with none of them employing a sample of the general population as study base [ 31].
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While some are actually "young", many suffer from multiple co-morbidities for which specific considerations have been summarized above [ 80].
We excluded the remaining morbidities for which no suitable algorithm could be identified (Additional file 1 Table S1).
For the MSD spectrum, we chose the morbidities for which pain symptoms are a common experience, Lower Back Pain (LBP), Osteoarthritis (OA) and Rheumatoid Arthritis (RA) [ 13].
Older patients are more likely to have multiple morbidities for which they are prescribed numerous medications, increasing their risk of experiencing adverse drug events (ADEs) [ 5].
Older patients often have numerous co-morbidities for which they are prescribed multiple medications, thereby increasing the risk of adverse drug events (ADEs) [ 1].
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