However, literature suggests that postoperative TJR patients may not reach pre-morbid levels of physical capacity [ 40, 41].
Informant-based instruments that assess functional ability are also prone to high degrees of variability due to varying pre-morbid levels of function and gender differences in the degree of participation in many of the functional activities that are assessed [ 31].
Most patients relate that they never return to their pre-morbid level of health [ 11, 12].
Baseline characteristics such as age, sex, pre-morbid level of work and shoulder dominance were recorded.
The majority of subjects met remission criteria while a minority reached their pre-morbid level of functioning, were regular with medication and with follow up at the hospital.
[ 12] In another cohort of COPD patients on mechanical ventilation for >14 days, survival at one year was associated with pre-morbid level of activity, FEV1, serum albumin level and severity of dyspnea.
Pre-morbid level of functioning (whether the participant could climb a flight of stairs and walk 800 m in the three months prior to hospital admission) and 12-month fall history will be collected during the baseline assessment.
While many have hypothesized that breast conservation will result in better post-treatment functioning than mastectomy, in reviewing the literature we found that adjusted physical function scores were not significantly different by treatment group, [ 12] but rather, largely related to women's general pre-morbid level of illness [ 16, 17, 40- 43].
Since no prospective data exist on the actual pre-morbid activity levels of individuals who later suffer a fatiguing illness, it is unclear whether our data reflect pre-morbid excessive activity, or alternatively, illness-related alterations in the perception or recall of premorbid activity.
If baclofen showed to have beneficial effects on psychiatric symptoms in these patients, baclofen might be specific interest for the treatment of those GHB dependent patients with co-morbid high levels of anxiety and depression.
Functioning has improved although not returning to pre-morbid levels.
