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The factors which could have influenced the patient outcome such as duration of disease, long term use of steroids or azathioprine, presence of fever, co morbid illnesses, preoperative hemoglobin, total leucocyte count and serum albumin levels were also recorded.
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However, our study has shown that critically ill patients who were older, male, and have underlying co-morbid illnesses were at higher risk for developing sARF and may represent a future target population for surveillance, earlier intervention or preventive strategies.
Nonetheless, long-term survival in this population has been more importantly associated with pre-morbid illnesses and functional ability at hospital discharge than with acute illness factors [14, 15].
Table S1 also demonstrates the distribution of co-morbid illnesses and details of hospital course by age group.
Over 90% of fatal cases had co-morbid illnesses; 80% had a co-morbid condition associated by the ACIP with severe seasonal influenza infection [3].
Patient hospitalizations were identified using ICD-9 and 10 codes in CIHI hospital discharge abstracts to longitudinally characterize subsequent events and co-morbid illnesses (Table S1).
HIV-1 co-infected patients may be at increased risk of acquiring nosocomial drug resistant pathogens because profound immune suppression results in co-morbid illnesses that require prolonged inpatient admissions.
Causes of clinical deterioration included AIDS-defining illnesses (according to WHO stage 4 criteria), non AIDS-defining HIV-related infections, TB-related illnesses, and illnesses unrelated to TB, i.e. co-morbid illnesses.
Potential causes for clinical deterioration in settings of high HIV-1 prevalence include drug resistant Mycobacterium tuberculosis (M.tb), co-morbid illnesses, poor adherence to therapy, tuberculosis associated-immune reconstitution inflammatory syndrome (TB-IRIS) and subtherapeutic antitubercular drug levels.
The associated co-morbid illnesses were monitored and treated appropriately.
Peripheral neuropathy, enteric illness and deep venous thrombosis were frequent co-morbid illnesses.
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