Co-morbidities will be collected using the Charlson Co-morbidity Index,[ 63] a weighted index that takes into account the number and seriousness of co-morbid diseases, to calculate a co-morbidity score for each subject.
Polygenic Risk Score has been used in studies of neuropsychiatric disorders to assess prediction of disease status in case-control studies, shared genetic correlation between co-morbid diseases, and shared genetic correlation between a disease and specific endophenotypes.
There have been several studies on neuropsychiatric disorders using the PRS to assess: Prediction of disease status in case-control studies, shared genetic correlation between co-morbid diseases, and shared genetic correlation between a disease and specific endophenotypes.
Let's use me as an example: Like many patients with Type 1 Diabetes, I have a number of co-morbid diseases, complications and diagnoses.
However, difficulties in obtaining sufficient numbers of adult EPCs from patients, as well as impaired function of these cells in patients with co-morbid diseases, may limit autologous stem cell therapies [6], [7].
Aside from co-morbid diseases, perceived discrimination and stigmatization leads to worsen outcomes in obese individuals.
Increased age, clinical stage and co-morbid diseases had a negative impact on survival.
Both co-morbid diseases and psychoactive medication use may explain fluctuations in CRBs during the study.
The patients self-reported on average 1.3 co-morbid diseases (median 1, range 1 11).
The co-morbid diseases of these patients might limit physician choices of treatment.
