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Previous reports suggested that these patients are likely to experience a morbid disease course.
Morbid disease genes have a higher node degree than random (P < 0.001).
Adenocarcinoma of the exocrine pancreas (pancreatic cancer) is a morbid disease with a dismal prognosis.
Despite the rigour of this work, the results are limited in capturing changes in underlying morbid disease.
Proteins of morbid disease genes have more interactions with each other than do proteins of randomly chosen genes.
We observe that there are significantly (P < 0.01) more interactions for proteins of morbid disease genes and HMPV-induced genes than random expectation in general PPI networks.
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An age-unadjusted Charlson co-morbidity Index score for assessing co-morbid disease was calculated for each patient, as described previously [ 41, 42].
Co-morbidity was categorised into a group without pre-existing disease, a group with one co-morbid disease and thirdly, a group with two or more co-morbidities.
Whilst it may have been appropriate during the acute illness, prolonged discontinuation may have had an effect on the stability of co-morbid disease in the longer term.
Because these diseases are typically co-morbid, multi-targeted drugs capable of interacting with multiple targets will expand treatment to the co-morbid disease condition.
Several factors have been identified that may predict for worse QOL outcomes including: the presence of a feeding tube, co-morbid disease, tracheotomy, site and stage.
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