Our primary objective was met as the immunogenicity of one priming dose of MenC-CRM at 3 months was non-inferior (and in fact was superior) to two MenC-CRM doses given at 3 and 4 months of age, when assessed at 13 months of age after the Hib-MenC-TT booster.
The lower reporting in January is somewhat contrary to the hypothesis that reporting on alcohol use is based on recall of recent drinking behavior, but is in line with a previous study which showed that reports of drinking in the past 12 months were lower when assessed in January compared to December [ 31].
This threshold coincides with the change observed in KOOS scores between 3 and 6 months postoperatively when assessing rehabilitation following reconstruction of the anterior cruciate ligament and concurs with the OARSI definition of moderate improvement in the knee pain assessment for clinical trials in OA [ 18, 22].
Of the 376 (9.5%) participants reporting self-harm behaviour at the first assessment, 207 (55.1%) continued to report self-harming acts when assessed six months later.
When assessed six months later, the participants' rating of the intensity of their hurt had declined significantly.
Although results were similar when assessed 3 months after the courses, for both knowledge domains, we found higher knowledge scores, particularly for Biostatistics, immediately after the on-site courses, than after the on-line course.
The increase in Research Ethics knowledge compared to baseline, was sustained when assessed 3 months after course completion and similar for both on-site and on-line formats (17% and 13% median knowledge gain, respectively; p = 0.14).
In contrast, the NPI improved group started at a worse level than the other two groups at baseline (29.8) but improved to a mean score of 18.6 when assessed 3 months later.
When assessed 6 months later, 458 (59.5%) continued to report self-harming thoughts, with girls being less likely than boys to report that they had stopped (OR = 1.42, 95% CI 1.06-1.91).
Among people with EM at baseline, when assessed every three months, 7.6% of individuals met headache day criteria for CM at least once over a 15-month period.
