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Child age in months, mother age in years and breast feeding in months were continuous covariates.
Primary end-points at 3, 6 and 12 months were continuous abstinence, point prevalence abstinence and reporting a 50% reduction in smoking.
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The target population were patients aged 18 years and above with confirmed diagnosis of asthma as defined by GINA 2007 guidelines [ 16], who have had asthma for at least 6 months, were on continuous asthma treatment within the 4 weeks preceding screening and whose asthma condition was partly controlled or uncontrolled.
Migrations of more than 2 mm between 12 and 24 months were considered to be "continuous migration" with increased risk of aseptic loosening.
All factors were continuous except for month.
BMI and follow-up time in months were examined as continuous numeric variables.
As patients may often stop treatment during an infection or elective surgery, any gaps in the use of the same anti-TNF treatment of less than 3 months were considered as continuous treatment.
Time (in months) was a continuous variable; March 2004 was recoded as 0, April 2004 as 1, and so on to March 2006 that was recorded as 24.
It is noted, however, that differences between 6 and 32 months are not continuous, linear changes since body weight and some muscle weights increase through late middle age (Lushaj et al. 2008).
Women who discontinued ART for more than 3 continuous months were excluded from the analysis during the time of treatment discontinuation.
Studies were excluded that were carried out only in adolescents (<18 years old), did not report continuous abstinence (≥6 months), were not carried out in the primary care setting or did not analyse the data by ITT.
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