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The union of genomic editing machinery, DNA inkjet printers, and bioinformatics algorithms allows engineers to design a library of thousands of unique oligos as well as build and test these designs on a ∼2 months time-scale and at a cost of roughly ∼0.3 cents per base pair.
In our study, we have utilized blood samples collected from stroke patients within 6 18 months in time scale from the index stroke.
Cox proportional hazards models were used, with months as the time scale, to estimate the risk of cardiovascular disease events or death according to oral hygiene.
We used age in months as the time scale in survival analyses with left truncation (i.e., participants entered into the cohort at different ages).
Cox proportional hazard models with time since diagnosis in months as the time scale were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for death from breast cancer.
Two sensitivity analyses were conducted: one used length of follow-up in calendar months as the time scale and age as covariate (10-year classes); another considered only a 6-month period instead of a 12-month period for the exclusion of cancers after inclusion and for the defined time lag for exposure to insulin glargine.
We used Cox proportional hazard models with time since diagnosis in months as the time scale to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for death from breast cancer (primary endpoint), death from other causes, or death from any cause as the endpoints, depending on the analysis.
Age (months) was the underlying time scale.
Cox proportional hazard models were used to estimate hazard ratios (HRs) for colorectal cancer with age (measured in months) as the underlying time scale, and robust standard error estimates to account for the dependence within twin pairs.
We analyzed the survival of 10,174 patients diagnosed with colorectal adenocarcinoma in Stockholm-Gotland and Linköping regions from 2000 to 2008, based on the Cox model using time since diagnosis (in months) as the underlying time scale (PROC PHREG, SAS Version 9.2).
Cox proportional hazard regression models with follow-up months as a primary time scale were used to estimate incidence rate ratios (RRs) and 95% confidence intervals (CIs) of developing endometrial cancer in each category of alcohol intake compared with nondrinkers as a reference (Cox, 1972).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com