The results from the logistic component of the Hurdle model (table 4) show that, for both all-cause and cardiovascular admissions, the significant differences found in the original SPHERE study at 18 months persist in the 12-month equivalent analysed here, but are not apparent at 24, 36, 48, 60 or 72 months.
The reduction in pain at 3 months persisted through to the 12-month follow-up point (figure 2), however, the median of pain group after 12 months (median=41, IQ1=31, IQ3=62) remained below the trial baseline median of 52 on the SF-36 bodily pain scale.
This faster growth rate of breast-fed infants after 4 months persisted up to 60 months of age.
We assumed that this numerical difference in survival at 30 months persisted without any further increases or decreases in long term survival.
The VA benefit of ranibizumab seen at 3 months persisted through 6 months, when the mean change from baseline VA increased to 11.6±14.0 letters for 0.3 mg ranibizumab and 11.8±14.1 letters for 0.5 mg ranibizumab.
Based on the results of another PA intervention in an older population, it was assumed that about 72% of the intervention effects on PA observed at 12 months persisted [ 50].
Despite the decreasing frequency of injections, the VA gained in the first 6 months persisted through the 3-year study period, suggesting a long-lasting treatment effect of ranibizumab in DME by using this treatment algorithm.
Finally, since the behaviour can considered to be a habit after one year, and based on the results of another PA intervention in an older population, it was assumed that about 72% of the intervention effects on PA observed at 12 months persisted after these 12 months when the intervention is not continued [ 50].
Importantly, a priori efficacy outcomes variables revealed a decrease of ∼50% in CHFS, Raynaud's severity and hand pain at 2 months with persisting benefits at 6 months.
He had resisted the temptation to restore the fit-again Wesley Sneijder after three months out, persisting with the same 4-4-2 line-up that had proved so successful in the Dutchman's absence.
