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A per-protocol analysis, including all subjects who completed the electronic diary during the three-month blinded follow-up, was used to compare subjects who completed three months of stimulation therapy in the AS group with subjects in the PS, MM and ancillary groups who also completed three months of follow-up.

After 12 months of stimulation, he said one patient had a five per cent increase and another had an eight per cent increase.

Almost all the mentioned therapies for RCM and CCH require weeks to months of stimulation for a prophylactic effect to occur, suggesting neuronal plasticity as a possible mechanism, and only stimulation of the sphenopalatine ganglion in CCH has demonstrated an acute, abortive effect [15].

Exogenous administration of GM1 ganglioside significantly reduces SG degeneration in deafened animals studied at 7 8 weeks of age, but after several months of stimulation, GM1-treated animals show only modestly better preservation of SG density compared to age-matched non-treated animals.

The reduction in seizure frequency in the second through fifth months of stimulation (months 6 through 9 post-implant) was significant compared to their preimplant baseline p = 0.04, paired t-test).

The baseline Y-BOCS score of 25 did not change significantly in the first 9 months of stimulation, but decreased dramatically to 10 and 14 points 12 and 15 months after surgery [ 32].

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Fontaine et al. [ 44] reported a second positive case: A 49-year-old man suffering from OCD as well as PD received bilateral stimulation of the STN, reducing Y-BOCS scores from a baseline of 32 to 1 after 6 months of active stimulation [ 44].

In the third patient [42] attack frequency dropped from 30/day to sporadic attacks after 15 months of continuous stimulation.

Mean Y-BOCS scores indicated a significant decrease of OCD symptoms after 12 months of active stimulation (from 32.2 ± 4.0 to 25.4 ± 6.7).

After 12 months of active stimulation 67% (i.e. four out of six) patients were classified as responders (≥35% Y-BOCS score decrease from baseline).

We compared two treatments (institutionalization and community living) and measured each elderly subject at five time points (2 months, 4 months, 6 months, 8 months, and 12 months) after the end of stimulation program for each neuropsychological test.

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