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Superficial lesion sometimes resolves spontaneously, but several months of antimicrobial drug are usually necessary.
Sputum cultures taken after 4, 6, and 9 months of antimicrobial drug therapy were negative.
In February 2014, after 15 months' of antimicrobial drug treatment, debridement, and skin grafting to the left foot, the lesions were completely healed.
However, successful treatment of osteomyelitis may require several months of antimicrobial therapy but should be guided by the patient's underlying condition and clinical response.
A minimum of 6 months of antimicrobial drug therapy is typically required for immunocompromised patients with pulmonary, bone and joint, or central nervous system infections (3 ).
Because treatment with oral amoxicillin/clavulanate or doxycycline has been associated with high relapse rates (9 ), we opted to give our patient combined amoxicillin/clavulanate and doxycycline to complete 6 months of antimicrobial drug therapy.
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The effects of individual characteristics and country on antimicrobial drug self-medication were studied with logistic regression analyses by using 3 outcome variables: actual self-medication in the previous 12 months, storage of antimicrobial drugs, and intended self-medication.
For parents, ORs were adjusted for sex, months of sampling, antimicrobial drug use within 1 month before the sample was taken, and active smoking.
Current recommendations for breast implant infection from M. fortuitum include 6 months of appropriate antimicrobial drug treatment in addition to implant removal because surgery alone yields relapse within 4 6 weeks (2, 3 ).
At 1, 3, 6, 9, and 12 months, the evaluation of antimicrobial activity of P. pentosaceus SB83 was performed as previously described.
This finding suggests that, although serotype 3 has increased as major OM pathogen in Costa Rican children > 24 months of age, common antimicrobial agents such as amoxicillin should be considered the first therapeutic option to treat these patients.
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