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Primary and secondary outcome measures are completed at baseline, after 3 months (completion of the 12 weekly sessions, core program), after completion of the program (12 months), and one year after completion of the program (24 months).
This is despite the fact that Flirtomatic is talking up the recent achievements under Curtis' watch, including the U.S. launch ("2m users in America in less than 18 months"), completion of the 2010 funding round, and making a number of new key hires.
To determine prospectively whether electroconvulsive therapy (ECT) produces structural brain changes, 35 inpatients with depression underwent magnetic resonance imaging before and twice after (at 2 to 3 days and at 6 months) completion of a course of brief-pulse, bilateral ECT.
Three conditions needed to be fulfilled before initiating the phase III part of the study: fast accrual rate (88 patients within 18 months), completion of full treatment in >60% of patients in the experimental arm, and ECRR of FOLFOX4 equal or superior to ECRR of cisplatin/fluorouracil.
Additional eligibility criteria included: being within 39 months of diagnosis to study enrollment (mean time = 23 months, 61% between 12 and 24 months), completion of chemotherapy or radiotherapy, no prior history of breast cancer or other cancer in the last 5 years.
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Treatment was continued for a median of 2 months (range, 0 47 months) after completion of chemotherapy.
Assessments were conducted prior to intervention, immediately after intervention, and 6 months and 18 months after completion of intervention.
Local failure occurred in four patients within 3 months of completion of CRT, four at 3 6 months, and three at greater than 12 months after completion of CRT.
The planned recruitment period is 18 months, and completion of follow-up 24 months after that.
Cranial MRI scans were performed 1 and 3 months after completion of local therapy, and every 3 months thereafter.
Six months after completion of chemotherapy, thrombotic deposits had completely resolved.
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