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As long as the DAS was ≤2.4 (from at least 6 months), combination therapy was tapered to monotherapy (usually methotrexate monotherapy), and then monotherapy was tapered to a maintenance dose.
Gemcitabine as monotherapy (four studies) and in combination therapy demonstrated a variable efficacy in terms of median OS (monotherapy: 6.0 months to 11.8 months; combination therapy: 14.7 months) and ORR (monotherapy: 6.7% to 21.2%; combination therapy: 3.8% to 50.0%).
At the end of the run-in period, 102 patients were randomly allocated to receive 12 months combination therapy with either repaglinide, insulin, and placebo metformin, or metformin, insulin, and placebo repaglinide.
Patients were randomized to 6 months combination therapy with interferon alpha-2b (3 MU tiw) and ribavirin (1000 1200 mg / day), 6 months ribavirin monotherapy (1000 1200 mg / day) or 6 months ribavirin placebo.
Improvement in systemic chemotherapy have increased median survival from 9 months when only 5-fluorouracil (5-FU) was available to more than 24 months combination chemotherapy and biological agents [ 5- 8].
In the largest comparative study so far, CIBIS-III [ 19], initiation of the beta-blocker bisoprolol for 6 months followed by 12 months combination therapy with an ACE inhibitor, was as effective as 6 months monotherapy with ACE inhibition, followed by another 12 months with the combination.
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While some financial institutions like Nationsbank move from one merger to the next within months, combinations of auto makers typically take years, as executives try to foster the cooperation needed to build reliable cars and trucks.
Venous thromboembolism (VTE) risk increases within months of combination oral contraceptive (COC) initiation.
Autologous platelet lysate or placebo buffer solution were applied twice per week for up to 9 months in combination with standardised compression bandaging.
As we have seen over the past 18 months, a combination of falling advertising (mainly classifieds), debt, increased competition and very poor sentiment have crushed equity value in names such as Johnston Press, ITV and Trinity Mirror.
It could well turn out that neither incentives nor intimidation nor, as seems likely in the coming months, some combination of the two, will achieve Beijing's professed aim of a harmonious, prosperous, unified China.
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