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Event rates for those with HF with preserved ejection fraction and a HF hospitalization in the 6 months before randomization were comparable with the rate in patients with HF and reduced ejection fraction with no previous HF hospitalization.Rates of cardiovascular death or HF hospitalization are greatest in those who have been previously hospitalized for HF.
Patients using oral antidiabetic drugs within the 3 months before randomization were excluded from the study.
The most recent GHb in the 12 months before randomization was used for baseline measurements.
IDUs were defined as patients who had injected drugs within the past 6 months before randomization.
Previous adjuvant chemotherapy was allowed provided that the last administration was given at least 6 months before randomization.
Although not actively questioned about symptoms of hypogonadism, 1 patient was known to have previously used testosterone treatment (stopped 3 months before randomization).
Similar(36)
The participants will be assessed four times over the course of 12 months: baseline before randomization, post-intervention (3 months), 6 months from baseline and 12 months from baseline.
Baseline assessment will be performed by evaluating the quality of end-of-life care in each pair of randomized wards for all eligible cancer deaths in the 3 months before the randomization date (months -1 to -3 in Figure 2).
As it is known that GI side effects occur early during treatment with metformin and resolve over time, a significant differential effect between these two groups was probably partially associated with the study design including a pretreatment period of at least 6 months with metformin before randomization.
Women who used hormone therapy before trial enrollment had mostly stopped such treatment, months or years before enrollment, and were otherwise required to undergo a 3-month washout before randomization.
Data will be extracted for a period of 12 months before and after randomization.
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days before randomization
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