In the 3 months before baseline, a small proportion (~4%) of patients had been admitted to the hospital for headache.
The frequency and proportion of patients who had visits or admissions between each visit is compared with those of the 3 months before baseline.
Conversely, HCP visits were more frequent; 42.9% of patients had a mean (SD) of 3.5 (4.0) HCP visits in the 3 months before baseline.
aRecent prior fracture within the last 12 months before baseline visit.
For some analyses, patients were categorised by previous TNFi use: TNFi-naive (never received TNFi therapy), TNFi-previous (washout: TNFi therapy discontinued for >2 months before baseline) and TNFi-recent (TNFi therapy discontinued for ≤2 months before baseline).
A distinction can be made between no previous injury, injuries sustained in the last 12 months before baseline measurements and injuries sustained more than 12 months before baseline measurements.
A distinction can be made between no previous injury, sustaining injured in the last 12 months before baseline measurements, and sustaining injured more than 12 months before baseline measurements.
Psychiatric hospitalization was best predicted by suicide threats in the 12 months before baseline and by prior hospitalization.
Patients had to have received prior MTX for ⩾6 months (stable dose ⩾10 mg/week for ⩾2 months before baseline).
41 Additional prespecified covariates included sex, count of comorbid conditions, education, and primary care visits six months before baseline.
Diabetes pharmacotherapy was defined by a ≥30-day supply of glycemia-lowering medication dispensed at a KPNC pharmacy during the 6 months before baseline (1 January 1998).
