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Monthly controls included: best corrected distance visual acuity (BCDVA-logMAR), foveal thickness (optical coherence tomography, OCT) and foveal function (multi-focal electroretinography, mfERG).
'He said:' We'll frame it as a normal pregnancy, and if you need monthly controls, we will do that, no problem.' So, that was strange.
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Reimbursement data was extracted from standardized monthly controlling reports for the same cost unit.
Patients were randomised to receive either monthly infliximab infusions (3 mg/kg infliximab with MTX 15 mg/week), or monthly control infusions and weekly MTX alone (<25 mg/week).
The participant then receives an e-mail message with their group assignment, instructions to upload on either a weekly (intervention) or monthly (control) basis, and is instructed to remove the sticker covering the pedometer face.
A smoothly varying intercept, h(t), where t = 1,…, T, T = 180, was added to both alternative models to allow for monthly control for the mean across all sites.
Depending on the number of patients opting for the six-monthly controls, we will compare this group with the six-monthly randomised group.
Patients with T2DM generally have three-monthly control visits with the practice nurse and a yearly consultation with their general practitioner (GP).
If three-monthly control in general practice could be reduced to six-monthly control in some patients, this would on the one hand reduce the use of medical services including involvement of practice nurses, and thus reduce costs, and on the other hand alleviate the burden of people with type 2 diabetes.
But the things that are happening are quite the opposite," he tells me, explaining that a centrally-monitored online sales register plus compulsory monthly VAT controls are hampering, not helping Czech companies.
They were enrolled as outpatients and gave their verbal informed consent to undergo the protocol (inpatient detoxification and three follow-up visits in the first year, then six-monthly clinical controls).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com