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Several medications have been applied to migraine patients as prophylaxis and most of these medications are able to reduce the monthly attack frequency by 50%[46]].
Figure 4 Correlation analysis between monthly attack frequency reduction and habituation change of N1 component after hand stimulation (p = 0.025, r = 0.62).
In contrast to CGRP (receptor) blockers, these have all been developed for diseases other than migraine and it is estimated that less than 50% of patients on prophylactics experience a 50% reduction in their monthly attack frequency [38].
High-resolution T1-weighted isotropic 3D MRI data acquired at 3 Tesla in 131 patients with migraine (92 patients without aura, 39 with aura; 31±9 years old; 109 women; monthly attack frequency: 3.2± 2.5; disease duration: 14±8.4 years) and 115 matched healthy subjects (29±7 years old; 81 women) were collected from 4 different centers (5 different scanners).
High-resolution 3D T-weighted MRI data were acquired at 3T in 131 migraineurs (31±9 years old; 109 women; monthly attack frequency: 3.2± 2.5; disease duration: 14±8.4 years) and 115 matched healthy subjects (29±7 years old; 81 women) at four international centers.
Finally, we used Pearson's test to search for correlations between the MR DTI parameters FA and MD, individual IC Z-max scores and clinical variables such as severity of headache attacks [0 10], duration of migraine history [years], monthly attack frequency [n], attack duration [hours], days elapsed since the last migraine attack [n].
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Although the proportion of migraine patients with WMH increased with the monthly migraine attack frequency (0 1 attack/month: n = 7/37, 18.9%, 2 7 attacks/month: n = 36/114, 31.5%, ≥8 attacks/month: n = 15/35, 42.9%), there was only a trend towards statistical significance (p = 0.08) when the patients were examined in three groups according to their attack frequency.
Specifically, there were increased risks for a migraine attack frequency of less than monthly (HR 1.9; 95% CI 1.2 3.1) and greater or equal to weekly (hazard ratio [HR] 4.3; 95% CI 1.4 13.3), but not for monthly migraine attacks [45].
Migraine attack frequency was 1 6/month.
Lost productive time correlated with attack frequency.
The attack frequency reduction was not significant.
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