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Participants will complete a 3 month weight loss intervention of decreased energy intake (EI) and increased exercise (100 min/week).

Participants who achieve ≥ 5% weight loss following a 6 month weight loss intervention delivered by phone conference call will be randomized to weight maintenance interventions delivered by conference call or conducted in a virtual environment (Second Life®).

It will be available in November for $119 and it costs $19.99 for a three month weight loss subscription.

Anthropometric, metabolic and hormonal variables were determined at baseline and, in a subgroup of children with hyperthyrotropinemia, after a six month weight loss program.

For example, Jakicic et al. compared the effects of different durations (1,000 kcal/week vs. 2,000 kcal/week) and intensities (moderate vs. vigorous) of exercise on 12 month weight loss.

26 More specifically, for obese adults attending a tertiary weight management clinic, shared care with general practitioners outperformed the specialist arm in short term (10 week) weight loss and dietary habits and achieved comparable six month weight loss.

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Of 432 potential participants screened by phone, 213 (49%) were eligible and of these, 189 (89%) completed baseline measures and were randomized to receive a 5-month weight loss intervention or a delayed intervention.

Participants (n = 72) are randomized to a 5-month weight loss intervention with or without the addition of a behavioral component that includes an innovative approach to promoting increased SPA.

In the fifth study (ULM), the control group followed an RCD for the first 3 months and then the PMR plan for the subsequent 9 months of treatment.11 Therefore, measurements from these subjects were excluded after completion of the 3-month weight loss phase.

Between groups, there were significant differences in 6-month weight loss (-4.1 kg VA-DPP vs -1.9 kg MOVE!, p<0.001), but not 12-month weight loss (-3.4 kg VA-DPP vs -2.0 kg MOVE!, p=0.16).

Although the between-group difference in 18-month weight loss was not statistically different (-1.3 kg [95% CI, -2.8 to 0.2 kg]; P =.09), there was a significant group × time interaction effect (P =.03).

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