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Applying, successively, a 1, 1.5, and 2-month time range buffer around each 6-month assessment point we observed a significant decrease in median standardized 24-month AUC of 1.68 EDSS-years (95% CI −2.51, −0.69), 1.59 EDSS-years (95% CI −2.47, −0.72), and 1.56 EDSS-years (95% CI −2.35, −0.75), respectively, in the natalizumab switch arm relative to the BRACE switchers.
The average costs of the different treatment strategies for the 12-month time frame range from €1362 for sertraline to €1401 for citalopram, €1394 for escitalopram, and €1385 for paroxetine.
The hypocenters determined by both land stations and OBS during the time range from July 8 to August 2 in 2000 are shown in the left side.
The time range of delay to accurate diagnosis was from 1 month to 6 months.
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While the CMVR in our patient occurred 1 month prior to the identification of thymoma, a thymic tumor was identified prior to the development of CMVR in the other eight patients, with a time ranging from 1 month to just over 6 years prior to the occurrence of retinitis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com