For physicians who said yes, the reported days per month of insulin omission/non-adherence was 4.3 for basal insulin and 5.7 for meal-related insulin.
One-month, percentage-based ratings of adherence had the strongest associations with MEMS and HbA1c; those requiring the report of missed doses had weaker associations.
The intervention's effects on adherence were assessed using an electronic pill bottle that automatically recorded the date and time of each opening (Medication Event Monitoring System, or MEMS; Aardex, Ltd ,Sion, Switzerland), providing an evaluation of adherence for the month before and the month after participants completed the intervention.
Experience of treatment side-effects will be assessed using a previously used measure at 3 month together with the measure of adherence.
Three quarters (72.5%) of physicians report that their typical patient does not take their insulin as prescribed, with a mean of 4.3 days per month of basal insulin omission/non-adherence and 5.7 days per month of prandial insulin omission/non-adherence.
This study will use graphical representation of adherence over an 8 month period, for the first time, to identify where further education or support may help improve long-term adherence to glaucoma medication.
Lastly, we examined long-term adherence, defined as the monthly average rate of adherence, comparing dose available in each month through prior dispensings in relation to dose prescribed in each month over a 24-month follow-up from time of first prescription.
The regression models demonstrated no significant association of adherence or persistence with 12-month fractures.
Similar predictors of adherence and discontinuation were also observed for 6-month and 12-month follow-ups and for an allowable 15-day and 30-day gap.
Starting from the 12th month, a monthly moving average and a monthly moving variance of adherence to HAART were calculated using, at each new monthly time point, the adherence over the previous twelve months.
