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However, in the monozygous twin study we found that in particular very-long-chain fatty acid-containing (e.g., nervonic acid, 24∶1) sphingomyelins are remarkably similar within obesity-discordant twin co-pairs [19].
A case of impactions of primary teeth which is generally rare was reported, however, this was associated with tooth agenesis in a monozygous twin [ 16].
Finally, a more decisive separation of genetic versus environmental effects would have come from examining the monozygous twin pairs separately, but the numbers are too small to permit this.
Similar(57)
Excepting identical (monozygous) twins, no two humans on Earth share exactly the same genomic sequence.
In twin studies the frequency of occurrence of the illness in both members of pairs of identical (monozygous) twins is compared with its frequency in both members of a pair of fraternal (dizygous) twins.
We have found previously that obesity in weight-discordant monozygous twins was primarily associated with elevated LPCs [19].
The genetic contribution to the overall variance in a phenotype can be estimated by comparing the intra-pair similarity of monozygous twins (MZ) and dizygous twins (DZ) [9], thus deriving an estimate of heritability (h2) [10].
It is possible that DNA methylation of disease-associated alleles may affect the relative risk of carriers to develop the trait, cause phenotypic heterogeneity or may explain some of the phenotypic differences in monozygous twins [44].
Compared to younger monozygous twins, older twins exhibited greater differences in DNA methylation.
The concordance rate for diabetes was substantially higher in monozygous twins compared with dizygous twins or siblings with CF (54).
Studies on monozygous twins suggest that AD may be caused by epigenetic factors, an explanation for different outcomes when the DNA sequence is conserved [ 2].
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