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Most progeroid syndromes where the aetiological factors are known are monogenic and segmental, in that they show many, but not all, of the clinical characteristics of normal ageing.
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Linardopoulou, E. V. et al. Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication.
Collectively, tandem and segmental duplication events were identified (Supplementary Table S6).
When the salamander regenerates its tail, the spinal cord grows back and segmental nerve-cell clusters (ganglia) differentiate.
Ka/Ks values indicated that most of the tandem and segmental duplication events were under purifying selection.
Some rashes with a symmetrical and segmental distribution may owe their pattern to the segmental arrangement of the embryo.
Bowel wall thickening may be focal and segmental or diffuse.
Whole-liver and segmental volumetry demonstrated no significant intraobserver variability for neither manual nor automated measurements.
The BLAST results identified two overlapping segmental duplications located on separate unplaced contigs (segmental duplication 1, contig NW_001839455.1 and segmental duplication 2, contig NW_001841142.1).
Daetwyler, H. D. et al. Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle.
First, the product of monogenic functions is in general not monogenic and second the composition of monogenic is in general not monogenic.
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