Sentence examples for monogenic and multifactorial from inspiring English sources

Genome mapping has previously been used with success to identify the genes involved in the development of both monogenic and multifactorial diseases.

Genes previously implicated in monogenic and multifactorial forms of diabetes are obvious candidates in this respect.

The diagnosis of ADH is difficult, due to the overlap of cholesterol values between monogenic and multifactorial forms.

Growing evidence of overlap in the genes involved in monogenic and multifactorial forms of diabetes [ 6] made this an excellent proposition.

The evidence so far (overlap between monogenic and multifactorial loci; growing numbers of loci with multiple independent association signals; extensive pleiotropy, and so on [ 23, 24]) provides some support for the former view.

Although there is sporadic evidence of participation of Africans in researching the genomics of rare monogenic [ 8] and multifactorial conditions [ 9], there is little evidence that this improved contribution of African researchers to research has an impact on wider public understanding of, attitudes to, and understanding of genomic medicine.

Thus, the traditional view of genetic disorders being either monogenic or multifactorial is no longer supported and requires a change in focus towards factors that modify gene expression and disease course.

Although linkage methods proved to be extremely successful in monogenic Mendelian diseases, their power of detection is minimal when they are used to explore the genetic bases of complex traits and multifactorial diseases (such as migraine) not showing a simple Mendelian pattern of transmission (refer also to the detailed literature list cited in [58]).

The etiology is poorly understood, and multifactorial.

Medical student training is dynamic and multifactorial.

Its mechanisms are complex and multifactorial.