So far, the only parts of this 'space' explored systematically are those occupied by rare, penetrant alleles (principally through linkage analysis of monogenic phenotypes) and common, mostly low-effect alleles (accessible through GWA analysis).
Some demographic and genetic features of this population, related to its insularity, offered the opportunity to study the impact of natural selection, for instance in determining resistance against malaria [1] and to clarify relevant aspects of the molecular bases of monogenic diseases common in Sardinia such as Thalassemia [2], Wilson disease [3], and APECED [4].
[1] Similarly, rare and common sequence variants within the ABCC8 gene have been associated with monogenic disorders (congenital hyperinsulinism of infancy), as well as sporadic type 2 diabetes.
The approach to tag monogenic and quantitative traits of agronomic interest in common bean previously relied on the application of BSA using AFLP, RAPD, or SSR markers, but this task proved to be tedious and time consuming.
These diseases are monogenic and inherited dominantly– and although rare they constitute the most common form of inherited neurodegenerative disorders.
The involvement of mitochondrial energy metabolism in human disease ranges from rare monogenic disease to common diseases and aging with a genetic and/or lifestyle/environmental cause.
The prevalence of common chronic non-communicable diseases (CNCDs) far overshadows the prevalence of both monogenic and infectious diseases combined.
The cellular models allow us to identify the mechanism of synaptic function or dysfunction in derived neurons from monogenic forms or common forms of obesity, and examine how they respond to different hormones and therapeutic agents.
First, the product of monogenic functions is in general not monogenic and second the composition of monogenic is in general not monogenic.
A q-monogenic function in Ω is monogenic, and thus harmonic in Ω.
