Paradoxically, while expenditure trended higher in the mono therapy group for outpatient service, the percent of patients using outpatient services (73.8%) was lower than in the LABA and LAMA therapy cohort (89.7%, p < 0.0001) and the LABA, LAMA and ICS therapy cohort (85.3%, p < 0.0001).
Several randomized controlled trials (RCTs) involving children with autism spectrum disorder (ASD) have examined effectiveness of mono-therapies for problem behavior.
The initial success of Tookad-VTP as a mono-therapy for localized prostate cancer [31], [34] is intriguing and strengthens our mechanistic claims.
Both studies recommend antibiotic combination therapy over mono-therapy for the initial empiric treatment phase of the most severely ill patients with septic shock [ 27, 28].
Whereas etanercept, adalimumab and certolizumab are approved as mono-therapy for RA, infliximab and golimumab are only approved in combination with MTX.
Much of the current research surrounds the use of PARP inhibitors as effective mono-therapy for breast and ovarian cancers with BRCA1 and BRCA2 mutations [ 54– 54].
Kernt et al (Kernt M, Ulbig M, Haritoglou C, et al, "Combination of Ranibizumab and Navigated Retinal Photocoagulation vs Ranibizumab Mono-Therapy for Diabetic Macular Oedema: Twelve Month Results".
Both cell lines were treated for 72 h with 10 μ M BIC, a non-steroidal anti-androgen currently used as mono-therapy for locally advanced or biochemically recurrent PCa.
26 An open label study by Stefan and colleagues exclusively evaluated an older cohort of 107 patients (mean age of 69 years) with TPM mono-therapy, for a one-year period.
111– 113 Hypofractionated HDR mono-therapy for prostate cancer has been gaining more attention from investigators, not only because of reduced in-hospital time for the patient, but also because of the low α/β ratio (1 to 2 Gy) of prostate cancer.
Mono-therapies for sepsis may be doomed to failure given the multiple redundant and reciprocating autonomic and cellular processes, intracellular pathways, different expression of common injury, variable times of presentation and differing initial clinical status, and variable levels of organ-system reserve, genetic predisposition, and nutritional state.
