Exact(1)
On comparing mouse skin and monkey ocular tissue bioavailability 8, it appears that bimatoprost accesses cutaneous tissue more readily and the tissue levels are better maintained than in ocular tissues.
Similar(59)
We characterized the dependence of motor learning in the monkey vestibulo-ocular reflex (VOR) on the duration, frequency, and relative timing of the visual and vestibular stimuli used to induce learning.
Finally, a recent investigation [57] using in situ hybridization showed a reduction in the expression of MW/LW and SW cone opsin mRNAs in monkeys with chronic ocular hypertension, consistent with our results.
The isopropyl ester of AL-16082, compound AL-16049, significantly lowered intraocular pressure (IOP) in the ocular hypertensive monkey eyes by 30%.
First, the effect of bimatoprost in the ocular hypertensive monkey model of glaucoma (Gagliuso et al., 2004) has been shown to be additive to that of latanoprost, the FP receptor agonist prodrug (Resul et al., 1997).
In fact, the same controversy existed in squirrel monkeys, "the only primate reported to lack ocular dominance columns" at that time (Horton and Hocking 1996).
Ocular administration of Na3VO4 to live monkeys significantly increases OF and reduces IOP.
Mice are thus not basically different in ocular dominance plasticity from cats and monkeys which is an absolutely essential prerequisite for their use as valid model systems of human visual disorders.
Though individual color domains in humans can be twice larger than those in monkeys (e.g., CO blobs are located in the centers of ocular dominance columns, and ocular dominance columns in humans are approximately twice larger than those in monkeys [cf. Adams et al. 2007; their Fig. 6C]), they are still much finer than the typical resolution that the current fMRI can offer.
It has been hypothesized that the different appearance of ocular dominance bands in the cat and the monkey is a consequence of the different mapping geometries in these species (LeVay et al. 1985; Anderson et al. 1988).
To the best of our knowledge, the maximum reported gain of ocular counter-rolling during static roll-tilt in monkeys was 0.24 (Krejcova et al. 1971).
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