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"We went back and found that the monkey data were incorrect," he said.
The human PK of a mAb can be reasonably estimated using cynomolgus monkey data and allometric scaling methods.
Human concentration time profiles were also reasonably predicted from the cynomolgus monkey data using species-invariant time method with a fixed exponent of 0.85 for CL and 1.0 for volume of distribution (Deng et al., 2011).
Despite biodistribution patterns being quite similar between species with all radiotracers, human effective dose using monkey data seems to be overestimated, with exposures to individual organs both over- and underestimated depending on the radiotracer.
Results of an unpublished Cortex trial performed after the monkey data became available indicate the drug improved wakefulness, memory, and attention in a small group of young British men kept awake for 27 hours.
Monkey data have shown that neurons in prefrontal cortex respond selectively to members of a learned category, irrespective of within category variations [18].
Similar(33)
Co-infected monkeys had similar frequencies of SIV-specific IFNγ-releasing cells compared to SIV-only monkeys (data not shown).
Western blots were positive for SIV Gag in all controls but negative in all Group 1A monkeys (data not shown).
No SSEA1 expressing germ cells were observed in the postnatal testes of 3-year-old and 5-year-old monkeys (data not shown).
No specific antigen was detected in the kidneys of challenged monkeys (data not shown).
No specific pathological changes were observed in the spleens of immunised monkeys (data not shown).
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CEO of Professional Science Editing for Scientists @ prosciediting.com