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We will use the gamma spending function[ 46] to monitor efficacy (gamma = -3, similar to O'Brien-Fleming) and futility (gamma = 0, similar to Pocock), spending Type I error, which monitors efficacy, slower than the Type II error, which monitors futility, in order to facilitate early stopping for either, but more so for futility.
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There is a need therefore to develop more specific tracers for both predicting and monitoring efficacy of chemotherapy.
From the monitoring efficacy, the high precision and good practical application have emerged.
Sixty-one patients with non-small cell lung cancer (NSCLC) who were scanned for monitoring efficacy of chemotherapy, molecularly targeted therapies or radiotherapy were included.
Both EGFR-TKIs, for which [18 F]FDG-PET as already demonstrated utility in monitoring efficacy [8], and MEK/Raf inhibitors are targeting the MAPK pathway.
The purpose of this committee will be to monitor efficacy and safety end points.
Independent Data and Safety Monitoring Committees were established to monitor efficacy and safety data.
The assay is suitable for use in clinical trials to monitor efficacy or pharmacodynamic effects of drug candidates.
A key limitation in the demonstration of monitoring efficacy in neurocritical care is the complexity of treatment generated by multimodality monitoring.
Some participants actively searched for information about the benefits and safety of HDS and experimented with HDS by monitoring efficacy and adverse effects.
Being a critical step in the cardiovascular continuum, endothelial function may serve as a surrogate marker to monitor efficacy of treatment.
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