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Intensive i.v. fluids and monitoring were started and the patient was transferred to the intensive care unit.

Under spontaneous respiration, a 22G needle was inserted into the right radial artery, and continuous arterial pressure monitoring was started.

According to the institutional post-CA care protocol, all patients were treated uniformly and BIS monitoring was started immediately after admission to CCU [19].

Hemodynamic monitoring was started at 0 h and continued until the end of both Studies 1 and 2 (Figure S1A and B in Additional file 1).

In both control and intervention groups, a continuous EEG monitoring is started within 2 h after randomisation and maintained during the first 48 h after randomisation and/or until body temperature normalisation in the therapeutic hypothermia group.

BIS monitoring was started 11 min after the cardiac arrest and showed an initial BIS value of 87 and an average value of 78 ± 5, a suppression ratio of 0 and a sufficient SQI (signal quality index, derived from impedance measurement of electrodes), which is considered to be above 50 (Fig. 1).

Monitoring was started 29 h after stroke.

At the same time, non-invasive esCCO monitoring was started.

ICP monitoring was started as soon as possible after admission.

Monitoring was started using 340 nm excitation and 642 nm emission filters.

At the time monitoring was started, all patients had a Glasgow Coma Scale ≤ 8.