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Several methods including immunoassays have been used for monitoring tacrolimus levels.
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Hence, it is of the utmost importance to monitor tacrolimus blood concentration, thereby ensuring clinical effect and avoiding toxic side effects.
Therefore, cyclosporine-A and tacrolimus levels have to be monitored exactly, and dose adjustments may be required.
Tacrolimus levels were not different between groups post-transplantation.
The tacrolimus levels were not elevated at any time as to be concerned about toxicity.
Neither was there any indication of a change in variability of tacrolimus levels on a group level.
We would recommend that tacrolimus levels are kept below 10 ng/ml after the second transplant month in straightforward transplants.
Fourteen patients experienced a change in tacrolimus levels >20% compared with baseline, no patients changed >20% in eGFR.
In addition, one-way ANOVA was performed to check whether the variation in tacrolimus levels changed after the conversion.
Four patients failed to follow the protocol; one patient switched gradually, two patients failed to give at least two post-conversion tacrolimus levels and one patient switched back to brand tacrolimus due to gastrointestinal discomforts.
Since 1995, Tacrolimus (TAC) was an alternative to CsA, given at 0.075 mg/kg to maintain serum tacrolimus levels within range 10 15 ng/ml and, since 1997, AZA was replaced by mycophenolate mofetil (MMF) (2 3 g/day).
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