Sample representation, interdependence between process parameters and their effects on powder flow behavior are critical factors for NIRS monitoring of continuous powder flow system.
With the prototype continuous mixer, two differently placed process interfaces for NIR spectroscopic monitoring of the powder mixing were evaluated.
In-line monitoring of continuous powder flow is an integral part of the continuous manufacturing process of solid oral dosage forms in the pharmaceutical industry.
A load cell (LC) was used to measure forces on the drum mounting frame and enable monitoring of bulk powder motion; SVS is a dynamic light scattering technique particularly suited for studying dynamics in dense, non-ergodic granular systems.
The implementation of statistical quality control methods for monitoring and control of powder abrasion/deposition is of increasing importance in a manufacturing environment.
Proper selection of NIR spectral preprocessing is of ultimate importance for successful implementation of this technology in the monitoring and control of powder blending and is discussed.
