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Coupled with the non-negligible costs of therapy, and the over-all worse prognosis of moderate-severe patients who are the usual recipients of biologic therapies, this challenging patients seem to be the first candidates for this more proactive strategy combining inflammatory and pharmacokinetic monitoring of objective inflammatory and pharmacokinetic measures.
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Efforts have been directed towards development of technology for continuous monitoring of more objective parameters to aid treatment (e.g. voice frequency readers, wrist-worn activity monitors, mobile electro-dermal activity sensors) (Mayora et al. 2013).
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Baseline data and long-term monitoring of measurable objectives are essential for effective evaluation, both to better tailor these innovative schemes to their aims, and to clearly demonstrate their benefits.
Data from 1985 2000 were used for this study if an annual mean was reported, regardless of the primary monitoring objective of the monitor.
Future directions also include advancing the technology of objective monitoring of cerebral function in order to allow better adaptation to the ICU setting (as compared with the operating theater) and demonstrating benefits in meaningful outcomes as a result of continuous, objective monitoring.
Real-time monitoring and the collection of objective and subjective data in one location offers a wide variety of opportunities for future research/clinical use.
Therefore, some form of objective monitoring, or quality control, of practices or procedures is needed so that periods of suboptimal performance in relation to an agreed standard can be recognised and, ideally, remedied.
The collaborative team decided that it was necessary a first study to determine the acceptability and validity of an application based solely on subjective information (SIMPLE 1.0), prior to the addition of objective monitoring data modules (SIMPLE 2.0) for three reasons: 1.
Recommendations Appoint a representative national advisory committee (comprising experts from the key providers) to ensure implementation, evaluation and monitoring of SHAPES' strategic objectives as proposed in the strategic plan.
The use of these cerebral function monitors as objective monitors of depth of sedation in the ICU has not yet been universally embraced.
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