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Many immune monitoring Consortia have been recently created worldwide to help facilitate and harmonize immune monitoring approaches in the cancer immunotherapy field and establish rigorous quality control standards for serial monitoring of immunologic functions.
Programmatic improvements led to increased uptake of the following clinical services from 2004 to 2008 (all P < 0.01): initiation of antiretroviral prophylaxis at ≤28 weeks gestation (IDUs 44%-54 44%-54IDUs 45%-72%), monitoring of immunologic (IDUs 45%-72%, non-IDUs 58%-80%) and virologic status (IDUs 8%-58%, non-IDUs 10%-75%), dual/triple antiretroviral prophylaxis (IDUs 9%-44%, non-IDUs 14%-59%).
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In addition, advances in HIV treatment, earlier diagnosis of infection status in exposed infants, and quantitative monitoring of virology and immunologic parameters may also have contributed to decreases in candidiasis rates.
We compared the HLA-A2 dimer assay to standard methods of immunologic monitoring (IFN-gamma release, lymphocyte proliferation, and cytotoxicity).
Simultaneously analysis by the dimer assay and standard immunologic assays demonstrated that the dimer-staining assay correlated well with these methods of immunologic monitoring.
The FC-HCS technique may be useful for a variety of applications including drug discovery, immunologic monitoring of patients, functional genomics studies and tissue engineering efforts.
Uptake of immunologic and virologic monitoring in both non-IDUs and IDUs also increased (Table 1).
Regardless of injection drug use history, we noted impressive improvements in the uptake of clinical services by HIV-infected women giving birth, such as earlier initiation of prenatal care, fewer unintended pregnancies, higher uptake of immunologic and virologic monitoring, earlier initiation and more complete antiretroviral prophylaxis.
Some controlled clinical trials have failed to show a benefit of VL monitoring over immunologic or clinical monitoring [ 21, 22].
A wide array of immunologic tests are available for immune monitoring in cancer vaccine trials, and the number of novel assays and technical modifications continues to burgeon.
Monitoring these immunologic biomarkers could improve prediction of relapse.
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