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This result suggested that cancer specific methylation changes in plasma and serum could be used in developing blood-based tests, which could be applied for risk assessment, earlier diagnosis and monitoring of cancers.
These molecules harbor specific features (stability, easy manipulation, reasonably simple detection, and tissue specificity) that can guide individualized treatments and monitoring of cancers.
Tumour-associated changes have been observed in the circulating nucleic acids of cancer patients and have been proposed to be useful for the detection and monitoring of cancers.
Due to this significant role of steroid receptors in tumor progression, these proteins represent excellent imaging targets for noninvasive molecular characterization and monitoring of cancers and benign disease states such as endometriosis.
Because this characteristic enhances both the survival and aggressiveness of cancer cells (24), it can adversely impact on some forms of treatment and it has potential for the detection and monitoring of cancers.
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They also play a vital role in the prevention, treatment and monitoring of cancer and are at the forefront of research to improve the length and quality of life of people with the disease,"said Dr Suzy Lishman, president of the Royal College of Pathologists.
Serial evaluations of treatment tolerability are an important component of clinical monitoring of cancer therapy [1].
Blood based molecular analyses ("liquid biopsies") are used for serial monitoring of cancer progression as well as the response to treatment [15].
Cancer is one of the main causes of death in today's world, therefore, extending fast and reliable approaches for early monitoring of cancer cells have become one of the great challenges for scientists.
The envisioned multifunctional smart nanodevice would contain the ability to (a) detect cancer at an early stage, (b) enhance imaging to pinpointing tumor location, (c) deliver drugs effective against the tumor, (d) and allow for monitoring of cancer cell eradication.
Given the significant utility of suberoylanilide hydroxamic acid (SAHA) in chemotherapeutic protocols, a PET tracer that mimics the histone deacetylase (HDAC) inhibition of SAHA could be a valuable tool in the diagnosis, treatment planning and treatment monitoring of cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com