These investigators found that estimating individual exposure to air pollutants from central-site outdoor pollution monitors may result in considerable error.
Additional limitations include the absence of indoor home monitoring and the use of fixed-site ambient pollution monitoring, which may result in exposure misclassification, particularly for ambient pollutants that have strong local sources (Briggs et al. 1997).
On the other hand, aggressive monitoring rules may result in an early termination for futility when the experimental arm is doing better than the control arm (in some cases nontrivially better, especially when trials are designed for unrealistically large effects).
Monitoring patients may result in different patterns of care by flexibly adjusting level of out-patient care in response to early signs of clinical deterioration.
An appropriate surveillance system is needed because the introduction of rubella vaccine without epidemiological data and an adequate monitoring program may result in the shifting of rubella cases to higher ages, and increased incidence of CRS.
Second, the use of data from only one monitoring site may result in exposure misclassification, though a recent study found that single site's temperatures and averaged temperatures from a network of sites had the similar ability to predict mortality as kriged spatial temperatures in Brisbane (Guo et al. 2012b).
8 These results are in keeping with our data, and the significant deterioration in performance from direct vision to monitor conditions may result from relative degradation of image quality or simply be a consequence of the unfamiliar and restrictive environment afforded by the box trainer.
However, the requirement for regular monitoring could also provide an opportunity to support adherence to warfarin therapy, and hence the lack of monitoring with dabigatran may result in poorer adherence to dabigatran therapy.
