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These parameters include the appropriateness of indication, dosing regimen, duration of therapy and monitoring for toxicity.
Although adverse events in children treated with propranolol have proven rare, the appropriate methods of assessing cardiovascular risk and monitoring for toxicity when the medication is used for infantile hemangiomas remain unclear.
Not a major interaction, but either capable of causing deterioration in clinical status, or where the manufacturer's SPC advises 'caution', or 'close monitoring' for toxicity or therapeutic failure.
Increased monitoring for toxicity is warranted for any such combination.
Monitoring for toxicity of deferoxamine includes regular ophthalmic (for visual fields) and audiological (for high frequency hearing loss) examinations.
On the basis of clinical judgment, we now use 150 mg of oseltamivir twice daily for severe cases, monitoring for toxicity.
Similar(49)
Unboosted atazanavir and fosamprenavir could possibly cause increases on voriconazole; therefore, monitoring for toxicities is necessary.
The rosuvastatin AUC is increased 48% with darunavir/RTV and the peak concentrations to 139%; therefore, the dose of rosuvastatin must be titrated carefully and the lowest necessary dose used, along with careful monitoring for toxicities.
Patients were monitored for toxicity at least weekly throughout treatment.
Patients were monitored for toxicity; 1-week dosing interruptions were permitted for dose-limiting toxicities.
Patients were monitored for toxicity (medical interview, physical examination and complete blood cell counts) during treatment.
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