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The action plan based on our findings would be worth considering when monitoring for internal quality control is difficult on site.
However, of the agency respondents, 44% reported that their company had formal compliance monitoring for internal standards and only 20% carried out publication audits.
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There were no significantly raised risks for the offspring of female workers monitored for internal exposure.
The transition m/z 257.3 to m/z 213.3 was monitored for internal standard.
The UK had identified anyone monitored for internal exposure, whereas the US and France identified anyone with a confirmed uptake.
Relative risks of cancer in offspring were estimated separately for female workers monitored for internal radiation exposure and other radiation workers.
Prostatic cancer mortality showed a statistically significant association with external radiation exposure, largely confined to men who were also monitored for internal contamination by radionuclides other than plutonium.
French and US workers with a known or suspected uptake were identified, as were UK workers who were known to have been monitored for internal exposure.
Between 1950 and 1994, 2,297 workers were monitored for internal radiation exposures, and 441 workers died, 134 (30.4%) of them from cancer as the underlying cause.
The major strengths of this study are the large number of workers including both male and female individuals who were monitored for internal plutonium exposure as well as external gamma radiation, the long follow-up period, the wide range of radiation exposures, the cancer registry and particularly the information available on confounding factors such as smoking and alcohol use.
Corresponding single transitions were monitored for each internal standard.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com