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Principles for designing electrocardiographic monitoring for cardiac safety in clinical trials are also reviewed.
Clinical studies using ErbB2-targeted inhibitors for the treatment of cancer should be designed to include careful monitoring for cardiac dysfunction.
The use of technology is gaining significance especially in teleheatlh applications for the continuous monitoring for cardiac patients and for special situations like treating a burn victim or monitoring infants having the risk of sudden infant syndrome.
Treatment involves reassuring the patient that the often frightening symptoms will pass, rehydration (fluid replacement) for fluid loss from vomiting, and monitoring for cardiac arrhythmias.
The study population included patients with cardiac disease, multisystem organ failure, acute heart failure, and severe sepsis, as well as patients needing postoperative monitoring for cardiac surgery.
Based on these negative findings in almost 500 TDEN-exposed subjects, we believe that specific monitoring for cardiac lesions in any future evaluation of this vaccine is unwarranted.
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In our study, patients were routinely monitored for cardiac events by clinical examination and every cycle evaluation of left ventricular ejection fraction.
In addition, 156 patients experienced minor non-cardiac toxicities; of 701 patients who were monitored for cardiac toxicities past the end of treatment, 10 and 44 patients showed CHF and decreased LVEF, respectively.
This study has the advantage of including the largest reported number of patients with post-SAH TCM who were successfully monitored for cardiac performance and volume status for approximately 14 days.
In terms of comparable investigations in humans, a study would need access to a population that is being continuously monitored for cardiac function as well as time-resolved PM2.5 compositional data.
Transesophageal echocardiography presents an alternative continuous, real-time monitoring option for cardiac function.
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