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The hierarchical control architecture includes five parts, which are: monitoring depth of anaesthesia (DOA), drug controller, deciding the sensitivity of the patient, narcotic supplementation and recovery time.

To assess a method for monitoring depth of anaesthesia using components of middle latency auditory evoked potential (AEP) waveforms during anaesthesia with fentanyl/fluanisone and midazolam.

Bispectral index (BIS) is a monitoring modality designed and used for monitoring depth of anaesthesia.

They suggested that such transitions might be useful in monitoring depth of anesthesia [ 49, 50].

It is unclear whether a BIS is effective for monitoring depth of anaesthesia during PDT, and further studies are needed to clarify this.

In the operating room, standard monitors (electrocardiogram, noninvasive blood pressure, pulse oximetry and capnography) and spectral entropy for monitoring depth of anesthesia were applied.

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Anesthesiologists commonly utilize processed electroencephalograms (EEG) in order to monitor "depth" of anesthesia, the most common of which is the Bispectral Index (BIS).

Bispectral Index, developed initially to monitor depth of anesthesia in the operating room [13, 20, 21], could be an approach.

In addition to pulse oximetry, capnography, and heart rate monitoring, all patients had a radial arterial line in place for continuous blood pressure monitoring and a BIS sensor in place to monitor depth of anesthesia.

It has been shown that the bispectrum of the EEG correlates with changes in consciousness level and the bispectral index (BIS) [5, 6] derived from EEG bispectral parameters was developed as a clinical tool to monitor depth of anaesthesia during surgery.

First, as noted, the BIS monitor was not continued in the ICU to monitor depth of sedation postoperatively.

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